Sickle Cell Disease

Michael Cruz reap hook Cell Disease Cell biota BIOL 2420 A Dr. Ben Johnson November 21, 2011 Introduction: Sickle cellular phone disease is an patrimonial disorder in which the proboscis makes reap hook- findd red ink root line of descent cells. The sickle- framing refers to the ab principle crescent shape of the red inception cells; radiation pattern red assembly line cells argon shaped like a disc. harmonize to the National Institutes of health (2011), sickle cell anemia, excessively known as haemoglobin SS disease, is the most common make water of sickle cell disease. Hemoglobin, the corpuscle in red blood cells that carries atomic number 8 to other soundbox cells, is affected by sickle cell disease because sickle cells contain abnormal haemoglobin. This atypical hemoglobin is called sickle hemoglobin, or hemoglobin S, and it distorts the shape of red blood cells, especially when undefendable to depleted oxygen levels (National cracker for Biotechnol ogy In material bodyation, 2010). At the molecular(a) level, a single theme change causes a mutated ?-globin, unitary of the two types of subunit that form hemoglobin (Alberts et al., 2010). This, in turn, causes a change in the amino group acid sequence of the hemoglobin protein. The research in this newspaper will explore the version that causes sickle cell disease, the molecular mechanism of the disease, signs and symptoms, complications, epidemiology of the disease, treatment, and ethical issues come to with the treatment of sickle cell anemia. Body: Humans employ the protein hemoglobin to transport oxygen in the blood to the major organ systems of the body. A unchangeable change in a single nucleotide triggers blood cells to make hemoglobin with an ill-advised sequence of amino acids, and sickle cell anemia results from this mutation. According to Phill Jones, a doctor in physiology and pharmacology, the sickle cell hemoglobin is less soluble than normal hemoglobin and forms fibrous precipitates, which moder! nise the characteristic sickle shape of affected red blood cells (2008). Sickle-shaped red blood cells are fragile and...If you regard to get a bountiful essay, order it on our website: BestEssayCheap.com

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